Effects of acute carbon monoxide posioning on liver damage and comparisons of related oxygen therapies in a rat model

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dc.contributor.authorGökdemir, Gül Şahika
dc.contributor.authorŞeker, Uğur
dc.contributor.authorDemirtaş, Berjan
dc.contributor.authorTaşkın, Seyhan
dc.date.accessioned2024-05-17T11:58:49Z
dc.date.available2024-05-17T11:58:49Z
dc.date.issued2024
dc.departmentMAÜ, Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractAcute carbon monoxide (CO) poisoning may cause liver damage and liver dysfunction. Therefore, in this study, we aimed to compare the efficiency of normobaric (NBO) and high flow nasal cannula oxygen (HFNCO) treatments on liver injury. For that purpose, twenty-eight male Wistar albino rats were divided into four groups (Control, CO, CO + NBO, CO + HFNCO). The control group was allowed to breath room air for 30 min. Acute CO poisoning in CO, CO + NBO, CO + HFNCO was induced by CO exposure for 30 min. Thereafter, NBO group received 100% normobaric oxygen with reservoir mask for 30 min. HFNCO group received high-flow oxygen through nasal cannula for 30 min. At the end of the experiment, all animals were sacrificed by cardiac puncture under anesthasia. Serum liver function tests were measured. Liver tissue TAS, TOS and OSI levels, tissue histomorphology and immunoexpression levels of Bax, Caspase 3, TNF-α, IL-1β, and NF-κB were also examined. Our observations indicated that acute CO poisoning caused significant increases in blood COHb, serum AST, ALT, ALP, total protein, albumin, globulin levels but a decrease in albumin to globulin ratio (all, p < 0.05). Furthermore, acute CO poisoning significantly increased the OSI value, and the immunoexpresssion of Bax, Caspase 3, TNF-α, IL-1β, and NF-κB in liver tissue (all, p < 0.05). These pathological changes in serum and liver tissue were alleviated through both of the treatment methods. In conclussion, both the NBO and HFNCO treatments were beneficial to alleviate the acute CO poisoning associated with liver injury and dysfunction.
dc.identifier.citationGokdemir, G., Seker, U., Demirtas, B., & Taskin, S. (2024). Effects of acute carbon monoxide posioning on liver damage and comparisons of related oxygen therapies in a rat model. Toxicology Mechanisms and Methods, 1–16. https://doi.org/10.1080/15376516.2024.2353887
dc.identifier.doi10.1080/15376516.2024.2353887
dc.identifier.endpage16
dc.identifier.pmid38721843
dc.identifier.scopusqualityN/A
dc.identifier.startpage107
dc.identifier.urihttps://doi.org/10.1080/15376516.2024.2353887
dc.identifier.urihttps://hdl.handle.net/20.500.12514/5880
dc.identifier.wosqualityQ2
dc.institutionauthorGökdemir, Gül Şahika
dc.institutionauthorid0000-0002-8691-1504
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.ispartofToxicology Mechanisms and Methods
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectApoptosis
dc.subjectCarbon monoxide
dc.subjectLiver toxicity
dc.subjectInflammation
dc.subjectNF-κB
dc.subjectNormabaric
dc.subjectHigh-flow nasal canule
dc.subjectMale rats
dc.titleEffects of acute carbon monoxide posioning on liver damage and comparisons of related oxygen therapies in a rat model
dc.typeArticle

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