Research on the effects of L-carnitine and trans-chalcone on endoplasmic reticulum stress and oxidative stress in high-fructose corn syrup-fed rats

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dc.contributor.authorÜnsal, Velid
dc.contributor.authorDeveci, Köksal
dc.contributor.authorÖzmen, Zeliha Cansel
dc.contributor.authorTümer, Mehmet Kemal
dc.date.accessioned2021-07-24T09:28:22Z
dc.date.available2021-07-24T09:28:22Z
dc.date.issued2021en_US
dc.departmentMAÜ, Fakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractPurpose: The debate on the metabolic effects of high fructose corn syrup (HFCS) continues. The deterioration of endoplasmic reticulum (ER) homeostasis is called ER stress. Glucose-regulated protein-78 (GRP-78) and X-box binding protein-1 (XBP-1) are key markers of ER stress and the therapeutic targets of diseases. Sterol regulatory element binding protein-1c (SREBP-1c) is the most important transcription factor that regulates the expression of enzymes for fatty acid synthesis. The purpose of this paper is to research the effects of L-carnitine and trans-chalcone on ER stress and oxidative stress parameters, and to explore the therapeutic potential of L-carnitine and trans-chalcone molecules. Design/methodology/approach: Forty male wistar albino rats randomly selected were divided into five groups. All groups are fed with standard chow (ad libitum). While Group I was fed with drinking water, Group II, III, IV and V were fed with water containing 15% HFCS. L-carnitine was given to Group IV and trans-chalcone to Group V, and both were dissolved with DMSO and given intraperitoneally. Group III was not given anything additional. Findings: While the amount of water consumption of HFCS-fed rats has increased, the amount of feed consumption has decreased. The weights of rats in Group II and Group III have increased significantly compared to Group I (p = 0.001, p = 0.001 respectively). In Group III, GRP78, XBP-1; malondialdehyde level (p < 0.001, p = 0.001, p = 0.041); total cholesterol, triglyceride, LDL levels (p = 0.001, p < 0.001, p = 0.009, p = 0.001, respectively) have increased significantly. Originality/value: To the best of the authors’ knowledge, this study is the first report to show that excessive HFCS consumption causes oxidative stress and ER stress. The antioxidant and antiobesity properties of trans chalcone have been demonstrated. Extensive experimental and clinical studies should be conducted.en_US
dc.description.sponsorshipThis study was supported by a grant from Gaziosmanpasa University, Tokat, Scientific Research Projects Commission Presidency (Project No: 2016/90).en_US
dc.identifier.endpage361en_US
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85087130298en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage345en_US
dc.identifier.urihttps://doi.org/10.1108/NFS-05-2020-0162
dc.identifier.urihttps://hdl.handle.net/20.500.12514/2690
dc.identifier.volume51en_US
dc.identifier.wosWOS:000547274500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherNutrition and Food Scienceen_US
dc.relation.ispartofNutrition and Food Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndoplasmic reticulum stressen_US
dc.titleResearch on the effects of L-carnitine and trans-chalcone on endoplasmic reticulum stress and oxidative stress in high-fructose corn syrup-fed ratsen_US
dc.typeArticleen_US

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