Investigation into the protective effects of Hypericum Triquetrifolium Turra seed against cyclophosphamide-induced testicular injury in Sprague Dawley rats

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dc.contributor.authorCan, Senanur
dc.contributor.authorÇetik Yıldız, Songül
dc.contributor.authorKeskin, Cumali
dc.contributor.authorŞahintürk, Varol
dc.contributor.authorCengiz, Mustafa
dc.contributor.authorAppak Başköy, Sıla
dc.contributor.authorAyhanci, Adnan
dc.contributor.authorAkıncı, Gülsema
dc.date.accessioned2022-10-10T06:34:13Z
dc.date.available2022-10-10T06:34:13Z
dc.date.issued2022en_US
dc.departmentMAÜ, Meslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümüen_US
dc.description.abstractFor centuries, Turkey has been a significant location here around 80 species of Hypericum with differing names widely occur, which is also known as Turkish folk medicine in treating some bacterial diseases as well as stomach and intestine inflammation. Recent studies have reported this herb family to contain numbers of bioactive compound contents. The study aims to investigate the protective effects of Hypericum triquetrifolium Turra (HT) upon oxidative stress and apoptosis in a rat model in which testes injury was induced by CP. The testicular injury was caused using CP (150 mg/kg). The rats were treated with a single dose (100 mg/kg) of methanol extract of HT to investigate various biochemical markers in the serum and plasma of blood samples apart from assessing the prognosis of CP-induced testicular damage. Added to that, histological analyses were performed to identify possible structural changes and apoptotic indicators, like Bax, Caspase-3, and Bcl-2. In CP Group, there was a rise in the levels of total oxidant status (TOS), malondialdehyde (MDA), oxidative stress index (OSI), Caspase-3, and Bax while superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), Bcl-2, and total antioxidant capacity (TAC) all decreased. Also, our histological analysis showed damaged testes. On the other hand, neither biochemical nor histological analysis showed testicular damage in HT Alone Group. In CP + HT Group, a significant number of the negatives changes due to CP were observed to have improved remarkably following an HT treatment. This study results suggest that HT could help improve CP-induced testicular injury thanks to its anti-oxidative and anti-apoptotic properties.en_US
dc.identifier.citationCan, S., Çetik Yıldız, S., Keskin, C., Şahintürk, V., Cengiz, M., Appak Başköy, S., ... & Akıncı, G. (2022). Investigation into the protective effects of Hypericum Triquetrifolium Turra seed against cyclophosphamide-induced testicular injury in Sprague Dawley rats. Drug and chemical toxicology, 45(4), 1679-1686.en_US
dc.identifier.doi10.1080/01480545.2020.1856130en_US
dc.identifier.endpage1686en_US
dc.identifier.issue4en_US
dc.identifier.pmid33280440en_US
dc.identifier.scopus2-s2.0-85097139015en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1679en_US
dc.identifier.urihttps://doi.org/10.1080/01480545.2020.1856130
dc.identifier.urihttps://hdl.handle.net/20.500.12514/3139
dc.identifier.volume45en_US
dc.identifier.wosWOS:000596284100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇetik Yıldız, Songül
dc.institutionauthorKeskin, Cumali
dc.language.isoenen_US
dc.publisherTaylor & Francis Onlineen_US
dc.relation.ispartofDrug and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyclophosphamideen_US
dc.subjectTesticular toxicity
dc.subjectHypericum triquetrifolium
dc.subjectTurra
dc.subjectAntioxidant
dc.subjectAnti-apoptotic
dc.titleInvestigation into the protective effects of Hypericum Triquetrifolium Turra seed against cyclophosphamide-induced testicular injury in Sprague Dawley ratsen_US
dc.typeArticleen_US

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