Effects of topiramate on inflammatory parameters in migraine prophylaxis
Yükleniyor...
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley Online Library
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim: Many medical agents are used in migraine prophylaxis. Topiramate is used as a
first-line treatment option for migraine prophylaxis. It has different side effects, but
its effects on inflammatory markers are unknown. In this study, we investigate the effects of topiramate in neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio
(PLR), and C-reactive protein (CRP) with migraine patients without aura.
Method: In this retrospective study, 60 healthy controls and 78 patients who were
followed up and had a diagnosis of migraine and took a topiramate therapy were
evaluated pretreatment, 3rd, and 6th months after treatment. The number of days
with pain, duration of pain, Migraine Disability Assessment Test (MIDAS), and Visual
Analog Scale (VAS) scores of the patients were evaluated before treatment and during
the controls.
Results and Conclusions: A significant decrease was observed in the painful days, duration of pain, MIDAS, and VAS scores in the evaluations in the 3rd and 6th month periods after the initiation of topiramate. Thrombocytopenia developed in one patient,
generalized paresthesia in two patients, and treatment was discontinued for these
patients. NLR, PLR, and CRP values before the topiramate treatment were statistically higher than the values at 3rd and 6th months of treatment. Neutrophil, platelet,
and lymphocyte counts also decreased during treatment. There was no statistically
significant difference between inflammatory parameters and number of days with
pain, duration of pain, MIDAS, and VAS scores. NLR, PLR, and CRP values decreased
topiramate therapy. Studies are needed to evaluate the anti-inflammatory effectiveness of topiramate in the treatment of migraine.
Açıklama
Anahtar Kelimeler
C-reactive protein, migraine, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, topiramate
Kaynak
Neurol Clin Neurosci
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
Sayı
Künye
Özdemir HH, Dönder A. (2022). Effects of topiramate on inflammatory parameters in migraine prophylaxis. Neurol Clin Neurosci. 2022;10:155–159.
doi:10.1111/ncn3.12592
