Investigation of serum ischemic-modified albumin, galectin-3, paraoxonase-1, and myeloperoxidase activity levels in patients with acute brucellosis

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dc.authorid0000-0003-0527-189Xen_US
dc.contributor.authorDündar, Ahmet
dc.date.accessioned2023-12-13T13:35:31Z
dc.date.available2023-12-13T13:35:31Z
dc.date.issued2023en_US
dc.departmentMAÜ, Meslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümüen_US
dc.description.abstractObjectives: Infection remains current as an important discussion topic in the etiological factors of atherosclerosis. Ischemic-modified albumin (IMA), galectin-3 (gal-3), paraoxonase-1 (PON-1), and myeloperoxidase (MPO) are biomolecules that play an important role in the pathogenesis of atherosclerosis. Our aim is to investigate serum IMA, gal-3, PON-1, and MPO activity in acute brucellosis infection. Materials and methods: Forty patients with acute brucellosis and 40 healthy individuals were included in the study. Serum IMA, gal-3, PON-1, and MPO activity were analyzed by the ELISA method. Results: In acute brucellosis infection, serum gal-3, IMA, and MPO activities were found to be significantly increased compared to the control group, and PON-1 activity was found to be significantly decreased compared to the control group (p < 0.001). There was a positive correlation between serum IMA, and MPO activity (r = 0.707 p = 0.000) and a negative correlation (r = -0.943, p = 0.000) between PON-1 activity. There was a positive correlation between serum gal-3 and MPO activity (r = 0.683, p = 0.000) and IMA level (r = 0.927, p = 0.000) and a negative correlation between PON-1 activity (r = -0.951, p = 0.000).Conclusion, it was found that serum gal-3, IMA levels and MPO activity increased, while PON-1 activity decreased. These results showed that the oxidant-anti-oxidant balance is impaired in acute brucellosis infection. In addition, these results indicate that brucella infection may be increase the risk of atherosclerosis. Further studies are needed to support our findings.en_US
dc.identifier.citationDündar A. (2023). Investigation of serum ischemic-modified albumin, galectin-3, paraoxonase-1, and myeloperoxidase activity levels in patients with acute brucellosis. Redox report : communications in free radical research, 28(1), 2289727. https://doi.org/10.1080/13510002.2023.2289727en_US
dc.identifier.doi10.1080/13510002.2023.2289727en_US
dc.identifier.issue1en_US
dc.identifier.pmid38054459en_US
dc.identifier.scopus2-s2.0-85178850509en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1080/13510002.2023.2289727
dc.identifier.urihttps://hdl.handle.net/20.500.12514/4668
dc.identifier.volume28"en_US
dc.identifier.wosWOS:001120571500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDündar, Ahmet
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relation.ispartofRedox Reporten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIMAen_US
dc.subjectMPOen_US
dc.subjectPON-1en_US
dc.subjectAcute brucellosisen_US
dc.subjectAtherosclerosisen_US
dc.subjectGalectin-3en_US
dc.titleInvestigation of serum ischemic-modified albumin, galectin-3, paraoxonase-1, and myeloperoxidase activity levels in patients with acute brucellosisen_US
dc.typeArticleen_US

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