Biological assays, electrochemical behavior, and theoretical DFT calculations of Ru(II) complexes of chiral phosphinite based based on β-amino alcohols: Transfer hyrogenation of ketones using a HCOOH/Et3N mixture

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dc.authorid0000-0002-7930-1054en_US
dc.contributor.authorRafikova, Khadichakhan
dc.contributor.authorMeriç, Nermin
dc.contributor.authorErtekin Binbay, Nil
dc.contributor.authorOkumuş, Veysi
dc.contributor.authorSever, M. Şerif
dc.contributor.authorBelyankova, Yelizaveta
dc.contributor.authorTursynbek, Saniya
dc.contributor.authorDauletbakov, Anuar
dc.contributor.authorSarah, Bayazit
dc.contributor.authorZolotareva, Darya
dc.contributor.authorYerassyl, Kamshyger
dc.contributor.authorDündar, Abdurahman
dc.date.accessioned2024-02-06T12:31:20Z
dc.date.available2024-02-06T12:31:20Z
dc.date.issued2024en_US
dc.departmentMAÜ, Meslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümüen_US
dc.description.abstractSynthesis of two phosphinite ligands based on β-amino alcohols, in high yields has been demonstrated. When we treated [Ru(arene)(μ-Cl)Cl]2 {arene:p-cymene,benzene} with chelating phosphinite ligands, we obtained neutral Ru(II)-complexes possessing the general formula [Ru(arene)phosphiniteCl2]. The structure of the ligands and complexes was confirmed using analytical and spectroscopic techniques. The quantum chemical calculations were carried out for the ruthenium complexes at the DFT/CAM-B3LYP level of theory in gas phase. The phosphinite complexes were subjected to cyclic voltammetry studies in order to determine the energies of HOMO and LUMO levels and to estimate their electrochemical and some electronic properties. Organic complex-based memory substrates were immobilized using TiO2-modified ITO electrodes, and the memory functions of phosphinite-based organic complexes were verified by chronoamperometry (CA) and open-circuit potential amperometry (OCPA). In the present study, the antioxidant potentials of ruthenium-based p-cymene and benzene complexes through DPPH radical scavenging, metal chelating, and reducing power activities were also determined. In addition, DNA binding abilities and antimicrobial activities of these complexes against pathogenic bacteria were studied. Finally, the ruthenium complex, (2S)-1-{[(2S)-2-[(diphenylphosphanyl)oxy]propyl][(1R)-1-phenylethyl]amino}propan-2-yldiphenyl phosphinitobis[dichloro(η6-benzene)ruthenium(II)] also catalyzed asymmetric transfer hydrogenation of acetophenone with high conversion (up to 99%) and good enantioselectivity (ee up to 89 %), in the existence of formic acid and triethylamine in dichloromethane medium under air atmosphere.en_US
dc.identifier.doi10.1016/j.molstruc.2024.137556en_US
dc.identifier.scopus2-s2.0-85183472027en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2024.137556
dc.identifier.urihttps://hdl.handle.net/20.500.12514/5749
dc.identifier.volume1303en_US
dc.identifier.wosWOS:001167959700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorDündar, Abdurrahman
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Molecular Structureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAsymmetric transfer hydrogenation (ATH)en_US
dc.subjectBiological assayen_US
dc.subjectCA and OCPAen_US
dc.subjectDFT and CAM-B3LYPen_US
dc.subjectElectrochemical propertiesen_US
dc.subjectΒ-amino alcoholsen_US
dc.titleBiological assays, electrochemical behavior, and theoretical DFT calculations of Ru(II) complexes of chiral phosphinite based based on β-amino alcohols: Transfer hyrogenation of ketones using a HCOOH/Et3N mixtureen_US
dc.typeArticleen_US

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