Protective Effect of Carvacrol Against Oxidative Stress and Heart Injury in Cyclophosphamide-Induced Cardiotoxicity in Rat

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dc.contributor.authorCetik, Songul
dc.contributor.authorAyhanci, Adnan
dc.contributor.authorSahinturk, Varol
dc.date.accessioned14.07.201910:50:10
dc.date.accessioned2019-07-16T20:44:03Z
dc.date.available14.07.201910:50:10
dc.date.available2019-07-16T20:44:03Z
dc.date.issued2015
dc.departmentMAÜ, Meslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümüen_US
dc.description.abstractPossible protective effects of carvacrol (Car) against cyclophosphamide (CP)-induced cardiotoxicity was examined in this study. Experimental groups of the rats were randomly divided into 13 groups, each including seven animals: Group 1 (control) treated with saline; groups 2, 3, and 4 treated with 50, 100, or 150 mg/kg of CP, respectively; group 5 treated with 0.5 mL olive oil; groups 6 and 7 treated with 5.0 and 10 mg/kg of Car, respectively; groups 8, 9, or 10 treated with respective CP plus 5.0 mg/kg of Car; and groups 11, 12, or 13 treated with respective CP plus 10 mg/kg of Car. Serum alanine transaminase (ALT), aspartat transaminase (AST), lactate dehydrogenase (LDH), malondialdehyde (MDA), creatine kinase-MB (CK-MB), total oxidant state (TOS), oxidative stress index (OSI), and levels were high only in the CP groups. There was a dose-dependence on the CP-induced cardiotoxicity. Hemorrhage, inflammatory cell infiltration and the separation of the muscle fibers in the heart tissue supported the biochemical data. With 5.0 and 10 mg/kg Car, there was an important decrease in the CP toxicity and this was related to the oxidative and nitrosative stress in the CP-induced cardiotoxicity. Reduced inflammation and lipid peroxidation in the heart tissue and increase of serum glutathione (GSH) and total antioxidant capacity (TAS) levels were found when carvacrol was applied. Based on these findings, it could be proposed that Car was a strong candidate in preventing the CP-induced cardiotoxicity but further clinical studies should be done in order to verify its application on humans.en_US
dc.identifier.citationCetik, S., Ayhanci, A., & Sahinturk, V. (2015). Protective Effect of Carvacrol Against Oxidative Stress and Heart Injury in Cyclophosphamide-Induced Cardiotoxicity in Rat. Brazilian Archives of Biology and Technology, 58(4), 569–576. https://doi.org/10.1590/s1516-8913201500022
dc.identifier.doi10.1590/S1516-8913201500022en_US
dc.identifier.endpage576en_US
dc.identifier.issn1516-8913
dc.identifier.issn1678-4324
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84940468645en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage569en_US
dc.identifier.urihttps://dx.doi.org/10.1590/S1516-8913201500022
dc.identifier.urihttps://hdl.handle.net/20.500.12514/1370
dc.identifier.volume58en_US
dc.identifier.wosWOS:000359309300011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherINST TECNOLOGIA PARANAen_US
dc.relation.ispartofBRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCyclophosphamideen_US
dc.subjectoxidative stressen_US
dc.subjectcardiotoxicityen_US
dc.subjectcarvacrolen_US
dc.subjectantioxidanten_US
dc.subjectraten_US
dc.titleProtective Effect of Carvacrol Against Oxidative Stress and Heart Injury in Cyclophosphamide-Induced Cardiotoxicity in Raten_US
dc.typeArticleen_US

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