Comparison of growth factor levels in injectable platelet-rich fibrin obtained from healthy individuals and patients with chronic periodontitis: a pilot study

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dc.contributor.authorKarcı, Bilge
dc.contributor.authorSavaş, Hasan Basri
dc.date.accessioned2024-05-09T10:22:41Z
dc.date.available2024-05-09T10:22:41Z
dc.date.issued2024
dc.departmentMAÜ, Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractBackground: This study aimed to assess and compare the concentrations of growth factors, white blood cells (WBCs), and platelets in injectable platelet-rich fibrin (i-PRF) derived from people with healthy periodontal conditions and those with chronic periodontitis. Methods: Venous blood samples were obtained from 30 patients diagnosed with chronic periodontitis (test group) and 30 participants with healthy periodontal conditions (control group). The i-PRF was then acquired from centrifuged blood. The growth factors (VEGF, IGF-1, TGF-β1, PDGF-BB and EGF) released from the i-PRF samples were compared between groups with ELISA testing. The amounts of WBCs and platelets were also compared. Results: No significant differences in the concentrations of growth factors were found between the groups (the mean values for the control and test groups were, respectively: IGF: 38.82, 42.46; PDGF: 414.25, 466.28; VEGF: 375.69, 412.18; TGF-β1: 21.50, 26.21; EGF: 138.62, 154.82). The test group exhibited a significantly higher WBC count than the control group (8.80 vs. 6.60, respectively). However, the platelet count did not show a statistically significant difference between the groups (control group 242.0 vs. test group 262.50). No significant correlation was observed between WBC count and growth factor level in either group. Conclusions: The growth factor levels in i-PRFs did not exhibit significant difference between the two groups. This suggests that the levels of these growth factors may be unaffected by the periodontal disease.
dc.identifier.citationKarcı, B., & Savas, H. B. (2024). Comparison of growth factor levels in injectable platelet-rich fibrin obtained from healthy individuals and patients with chronic periodontitis: a pilot study. BMC oral health, 24(1), 527. https://doi.org/10.1186/s12903-024-04301-x
dc.identifier.doi10.1186/s12903-024-04301-x
dc.identifier.issue1
dc.identifier.pmid38702671
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.1186/s12903-024-04301-x
dc.identifier.urihttps://hdl.handle.net/20.500.12514/5872
dc.identifier.volume24
dc.identifier.wosqualityQ2
dc.institutionauthorSavaş, Hasan Basri
dc.institutionauthorid0000-0001-8759-4507
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofBMC Oral Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChronic periodontitis
dc.subjectGrowth factors
dc.subjectInjectable platelet rich fibrin
dc.subjectPlatelets
dc.subjectWhite blood cells.
dc.titleComparison of growth factor levels in injectable platelet-rich fibrin obtained from healthy individuals and patients with chronic periodontitis: a pilot study
dc.typeArticle

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