Cyclophosphamide induced oxidative stress, lipid per oxidation, apoptosis and histopathological changes in rats: Protective role of boron
Yükleniyor...
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background
Cyclophosphamide (CP) is an alkylating chemotherapeutic drug used in the treatment of many types of cancer. However, as with other chemotherapeutic drugs, the use of CP is limited by the damage to healthy tissues such as testes, bladder and liver as well as cancerous tissue. Boron (B) is a trace element with many biological properties such as antioxidant, anti-apoptotic and anti-lipid per oxidation.
Methods
This current study aims to determine protective effects of B on CP induced testicular toxicity. The rats were divided into 4 groups (control, CP, B and B plus CP groups). The testes of experimental animals were taken for histological, apoptotic markers and biochemical analysis.
Results
The damage to some seminifer tubules, loss of typical appearance, thinning of seminifer epithelium and relative enlargement of the tubule lumen were watched in testis of the group that administrated CP. Moreover, Bcl-2, TAC and GSH levels decreased while TOC, OSI, MDA, Bax and Caspase-3 levels increased. On the other hand, pretreatment limited to B in the B plus CP group, testicular tissue improved. In addition, Bcl-2, GSH, TAC levels increased, Bax, MDA, TOC, OSI and caspase-3 levels decreased.
Conclusion
B significantly reduced testicular lipid per-oxidation and strengthened antioxidant defenses. Our results showed that pre-treatment B can protect rat testis against CP-induced testicular damage owing to its anti-lipid per oxidation, anti-oxidant and anti-apoptotic properties.
Açıklama
Anahtar Kelimeler
CyclophosphamideTesticular damageApoptosisBoronAnti-OxidantLipid per oxidation
Kaynak
Journal of Trace Elements in Medicine and Biology
WoS Q Değeri
Q3
Scopus Q Değeri
N/A
Cilt
62
Sayı
0
Künye
Cengiz M, Sahinturk V, Yildiz SC, Şahin İK, Bilici N, Yaman SO, Altuner Y, Appak-Baskoy S, Ayhanci A. Cyclophosphamide induced oxidative stress, lipid per oxidation, apoptosis and histopathological changes in rats: Protective role of boron. J Trace Elem Med Biol. 2020 Dec;62:126574. doi: 10.1016/j.jtemb.2020.126574. Epub 2020 May 30. PMID: 32516632.
Bağlantı
https://www.scopus.com/record/display.uri?eid=2-s2.0-85085993113&origin=resultslist&sort=plf-f&src=s&sid=a7fc8a6fce1eb778a866f0618b224f81&sot=b&sdt=b&sl=32&s=DOI%2810.1016%2fj.jtemb.2020.126574%29&relpos=0&citeCnt=6&searchTerm=
https://pubmed.ncbi.nlm.nih.gov/32516632/
https://doi.org/10.1016/j.jtemb.2020.126574
https://hdl.handle.net/20.500.12514/2820
https://pubmed.ncbi.nlm.nih.gov/32516632/
https://doi.org/10.1016/j.jtemb.2020.126574
https://hdl.handle.net/20.500.12514/2820
