Cyclophosphamide induced oxidative stress, lipid per oxidation, apoptosis and histopathological changes in rats: Protective role of boron

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dc.authorid0000-0002-7855-5343en_US
dc.contributor.authorCengiz, Mustafa
dc.contributor.authorŞahintürk, Varol
dc.contributor.authorCetik Yildiz, Songul
dc.contributor.authorKurcanay Şahin, İlknur
dc.contributor.authorBilici, Namık
dc.contributor.authorOnur Yaman, Suzan
dc.contributor.authorAltuner, Yılmaz
dc.contributor.authorAppak-Baskoy, Sıla
dc.contributor.authorAyhanci, Adnan
dc.date.accessioned2021-08-26T06:33:06Z
dc.date.available2021-08-26T06:33:06Z
dc.date.issued2020en_US
dc.departmentMAÜ, Meslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümüen_US
dc.description.abstractBackground Cyclophosphamide (CP) is an alkylating chemotherapeutic drug used in the treatment of many types of cancer. However, as with other chemotherapeutic drugs, the use of CP is limited by the damage to healthy tissues such as testes, bladder and liver as well as cancerous tissue. Boron (B) is a trace element with many biological properties such as antioxidant, anti-apoptotic and anti-lipid per oxidation. Methods This current study aims to determine protective effects of B on CP induced testicular toxicity. The rats were divided into 4 groups (control, CP, B and B plus CP groups). The testes of experimental animals were taken for histological, apoptotic markers and biochemical analysis. Results The damage to some seminifer tubules, loss of typical appearance, thinning of seminifer epithelium and relative enlargement of the tubule lumen were watched in testis of the group that administrated CP. Moreover, Bcl-2, TAC and GSH levels decreased while TOC, OSI, MDA, Bax and Caspase-3 levels increased. On the other hand, pretreatment limited to B in the B plus CP group, testicular tissue improved. In addition, Bcl-2, GSH, TAC levels increased, Bax, MDA, TOC, OSI and caspase-3 levels decreased. Conclusion B significantly reduced testicular lipid per-oxidation and strengthened antioxidant defenses. Our results showed that pre-treatment B can protect rat testis against CP-induced testicular damage owing to its anti-lipid per oxidation, anti-oxidant and anti-apoptotic properties.en_US
dc.identifier.citationCengiz M, Sahinturk V, Yildiz SC, Şahin İK, Bilici N, Yaman SO, Altuner Y, Appak-Baskoy S, Ayhanci A. Cyclophosphamide induced oxidative stress, lipid per oxidation, apoptosis and histopathological changes in rats: Protective role of boron. J Trace Elem Med Biol. 2020 Dec;62:126574. doi: 10.1016/j.jtemb.2020.126574. Epub 2020 May 30. PMID: 32516632.en_US
dc.identifier.doi10.1016/j.jtemb.2020.126574en_US
dc.identifier.endpage6en_US
dc.identifier.issue0en_US
dc.identifier.pmid32516632en_US
dc.identifier.scopus2-s2.0-85085993113en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85085993113&origin=resultslist&sort=plf-f&src=s&sid=a7fc8a6fce1eb778a866f0618b224f81&sot=b&sdt=b&sl=32&s=DOI%2810.1016%2fj.jtemb.2020.126574%29&relpos=0&citeCnt=6&searchTerm=
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/32516632/
dc.identifier.urihttps://doi.org/10.1016/j.jtemb.2020.126574
dc.identifier.urihttps://hdl.handle.net/20.500.12514/2820
dc.identifier.volume62en_US
dc.identifier.wosWOS:000586028000015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Trace Elements in Medicine and Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası - Editör Denetimli Dergien_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyclophosphamideTesticular damageApoptosisBoronAnti-OxidantLipid per oxidationen_US
dc.titleCyclophosphamide induced oxidative stress, lipid per oxidation, apoptosis and histopathological changes in rats: Protective role of boronen_US
dc.typeArticleen_US

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