Cardioprotective effects of Hypericum triquetrifolium Turra. against cyclophosphamide related cardiotoxicity in rats

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dc.contributor.authorÇetik Yıldız, Songül
dc.contributor.authorKeskin, Cumali
dc.contributor.authorŞahintürk, Varol
dc.contributor.authorAyhancı, Adnan
dc.date.accessioned14.07.201910:50:10
dc.date.accessioned2019-07-16T20:43:54Z
dc.date.available14.07.201910:50:10
dc.date.available2019-07-16T20:43:54Z
dc.date.issued2018
dc.departmentMAÜ, Meslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümüen_US
dc.description.abstractCyclophosphamide (CYP) is commonly used as anticancer agent but its usage is limited by cardiotoxic side effects such as dose-dependent cardiac damage, morphologically defined necrosis and bleeding. Hypericum triquetrifolium Turra. (HT) shows anti-oxidative and anticarciogenic properties with its rich phenolic contents. The current study was designed to investigate the possible protective effect of HT on CYP-induced cardiotoxicity. Albino rats were randomly divided into 9 groups, each included 7 animals. Serum creatine kinase-MB (CK-MB), malondialdehyde (MDA), aspartate transaminase (AST), glutathione (GSH), total antioxidant (TAC) and total oxidant capacity (TOC) levels were investigated. Furthermore, the cardiac tissue samples were investigated histopatologically. While the levels of serum CK-MB, MDA, AST and TOC were high, the levels of serum GSH and TAC levels were low in the CYP groups. It was also observed that CYP-induced cardiotoxicity was dose dependent. In the treatment with CYP plus HT doses there was observed an essential decrease in the CYP cardiotoxicity; decreased cell damage and oxidative stress parameters and also increased GSH and TAC levels. Based on our findings, it can be proposed that HT seed methanol extract was a strong candidate in preventing the CYP-induced cardiotoxicity.en_US
dc.description.sponsorshipMardin Artuklu University - Coordination Unit of Scientific Research Project [MAU-BAP-15-SHMYO-23]en_US
dc.description.sponsorshipThis study was supported by Mardin Artuklu University - Coordination Unit of Scientific Research Project (MAU-BAP-15-SHMYO-23). This study was approved by the by the Rectorate of Eskisehir Osmangazi University Local Ethics Committee of Animal Experiments with the number 444-1 / 2015.en_US
dc.identifier.citationYILDIZ S. Ç,KESKİN C,ŞAHİNTÜRK V,AYHANCI A (2018). Cardioprotective effects of Hypericum triquetrifoliumTurra. against cyclophosphamide related cardiotoxicity in rats. Marmara Pharmaceutical Journal, 22(3), 374 - 385. Doi: https://doi.org/10.12991/jrp.2018.77
dc.identifier.doi10.12991/jrp.2018.77en_US
dc.identifier.endpage385en_US
dc.identifier.issn2630-6344
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85056604153en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage374en_US
dc.identifier.urihttps://dx.doi.org/10.12991/jrp.2018.77
dc.identifier.urihttps://hdl.handle.net/20.500.12514/1264
dc.identifier.volume22en_US
dc.identifier.wosWOS:000445922100005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherMarmara Pharmaceutical Journalen_US
dc.relation.ispartofJOURNAL OF RESEARCH IN PHARMACYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCardiotoxicityen_US
dc.subjectCyclophosphamideen_US
dc.subjectCardioprotective effectsen_US
dc.subjectHypericum triquetrifolium Turra.en_US
dc.titleCardioprotective effects of Hypericum triquetrifolium Turra. against cyclophosphamide related cardiotoxicity in ratsen_US
dc.typeArticleen_US

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