Sinapic acid reduces ischemia/reperfusion injury due to testicular torsion/detorsion in rats
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Andrologia
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
This study aimed to investigate the protective effect of sinapic acid (SA) on biochemical and histopathological changes in an experimental testicular torsion-detorsion rat model. Twenty-four rats were randomised into four groups: sham group, ischemia/reperfusion (IR) group subjected to testicular torsion for 2 hr and then detorsion for 4 hr, and two groups treated with SA1 and SA2 (10 mg/kg and 20 mg/kg, by single intraperitoneal injection, 30 min before reperfusion). Serum testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were measured by an autoanalyzer, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA), protein carbonyl (PC), and nitric oxide (NO) oxidative stress parameters by spectrophotometric methods, and tumour necrosis factor (TNF-α), interleukin-1 beta (IL-1β), and interleukin 6 (IL-6) parameters by the Elisa method. In addition, immunohistochemical and histopathological examinations were performed on testicular tissues. There was no significant difference between the groups in terms of serum testosterone, FSH and LH levels (p >.05). SA significantly reduced increased testicular damage, oxidative stress, inflammation, cell death and also restored decreased antioxidant enzyme activities (p <.05). Pre-treatment of rats with SA reduced testicular dysfunction and morphological changes IRI. SA's antioxidant, anti-inflammatory, and antiapoptotic properties were found to be protective against testicular IR
Açıklama
Anahtar Kelimeler
inflammation apoptosis, oxidative stress, sinapic acid, testicular torsion-detorsion
Kaynak
Andrologia
WoS Q Değeri
Q3
Scopus Q Değeri
N/A
Cilt
Sayı
Künye
Unsal V, Kolukcu E, Gevrek F, Firat F. Sinapic acid reduces ischemia/reperfusion injury due to testicular torsion/detorsion in rats. Andrologia. 2021 Sep;53(8):e14117. doi: 10.1111/and.14117. Epub 2021 Jun 3. PMID: 34081348.
Bağlantı
https://www.scopus.com/record/display.uri?eid=2-s2.0-85107062951&doi=10.1111%2fand.14117&origin=inward&txGid=dc7834224eec439793222286bb2f0383
https://hdl.handle.net/20.500.12514/2709
https://doi.org/10.1111/and.14117
https://pubmed.ncbi.nlm.nih.gov/34081348/
https://www.webofscience.com/wos/woscc/full-record/WOS:000657420900001?AlertId=d383397b-4355-449e-9419-70f9e0e77c15&SID=D1hazuxYdSuegRDn8zn
https://hdl.handle.net/20.500.12514/2709
https://doi.org/10.1111/and.14117
https://pubmed.ncbi.nlm.nih.gov/34081348/
https://www.webofscience.com/wos/woscc/full-record/WOS:000657420900001?AlertId=d383397b-4355-449e-9419-70f9e0e77c15&SID=D1hazuxYdSuegRDn8zn
