Sinapic acid reduces ischemia/reperfusion injury due to testicular torsion/detorsion in rats

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dc.contributor.authorUnsal, Velid
dc.contributor.authorKölükçü, Engin
dc.contributor.authorGevrek, Fikret
dc.contributor.authorFırat, Fatih
dc.date.accessioned2021-07-28T08:16:03Z
dc.date.available2021-07-28T08:16:03Z
dc.date.issued2021en_US
dc.departmentMAÜ, Fakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractThis study aimed to investigate the protective effect of sinapic acid (SA) on biochemical and histopathological changes in an experimental testicular torsion-detorsion rat model. Twenty-four rats were randomised into four groups: sham group, ischemia/reperfusion (IR) group subjected to testicular torsion for 2 hr and then detorsion for 4 hr, and two groups treated with SA1 and SA2 (10 mg/kg and 20 mg/kg, by single intraperitoneal injection, 30 min before reperfusion). Serum testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were measured by an autoanalyzer, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA), protein carbonyl (PC), and nitric oxide (NO) oxidative stress parameters by spectrophotometric methods, and tumour necrosis factor (TNF-α), interleukin-1 beta (IL-1β), and interleukin 6 (IL-6) parameters by the Elisa method. In addition, immunohistochemical and histopathological examinations were performed on testicular tissues. There was no significant difference between the groups in terms of serum testosterone, FSH and LH levels (p >.05). SA significantly reduced increased testicular damage, oxidative stress, inflammation, cell death and also restored decreased antioxidant enzyme activities (p <.05). Pre-treatment of rats with SA reduced testicular dysfunction and morphological changes IRI. SA's antioxidant, anti-inflammatory, and antiapoptotic properties were found to be protective against testicular IRen_US
dc.identifier.citationUnsal V, Kolukcu E, Gevrek F, Firat F. Sinapic acid reduces ischemia/reperfusion injury due to testicular torsion/detorsion in rats. Andrologia. 2021 Sep;53(8):e14117. doi: 10.1111/and.14117. Epub 2021 Jun 3. PMID: 34081348.
dc.identifier.endpage14
dc.identifier.pmid34081348en_US
dc.identifier.scopus2-s2.0-85107062951en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85107062951&doi=10.1111%2fand.14117&origin=inward&txGid=dc7834224eec439793222286bb2f0383
dc.identifier.urihttps://hdl.handle.net/20.500.12514/2709
dc.identifier.urihttps://doi.org/10.1111/and.14117
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/34081348/
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000657420900001?AlertId=d383397b-4355-449e-9419-70f9e0e77c15&SID=D1hazuxYdSuegRDn8zn
dc.identifier.wosWOS:000657420900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAndrologiaen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectinflammation apoptosis, oxidative stress, sinapic acid, testicular torsion-detorsionen_US
dc.titleSinapic acid reduces ischemia/reperfusion injury due to testicular torsion/detorsion in ratsen_US
dc.typeArticleen_US

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