The protective effects of sinapic acid on acute renal ischemia/reperfusion injury
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Journal of Biochemistry
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objectives: The aim of this research was to investigate whether sinapic acid (SA) can alleviate oxidative damage, apoptosis, and inflammation in I/R induced renal injury. Methods: A total of 24 male rats were randomly separated into four groups as six rats in each group. Group 1 (Sham), Group 2 (I/R), Group 3 (I/R + SA, 10mg/kg), Group 4 (I/R + SA, 20 mg/kg). In order to evaluate kidney function serum BUN, Cr, and AST were measured in an autoanalyzer. SOD, GSH-Px, MDA, PC and NO oxidative stress parameters were measured with spectrophotometric methods and TNF-α, IL-1β, IL-6, KIM-1 and NGAL parameters were measured with the ELISA method. In addition, H&E method and immunohistochemical examinations were performed for histological evaluations of kidney tissue. Results: SA significantly decreases the increase in kidney damage, inflammation, oxidative stress, cell death and restore the decrease in antioxidant enzyme activities (p<0.05). Pre-treatment of the rats with SA reduces kidney dysfunction and morphological changes. Conclusions: The development of oxidative stress and lipid peroxidation seems to be the leading factors that accelerate inflammation and cell death during renal IRI. The antioxidant, anti-inflammatory, and anti-apoptotic features of SA displayed a renoprotective effect.
Açıklama
Anahtar Kelimeler
Apoptosis; Kidney; KIM-1; NGAL; Oxidative stress; Sinapic acid
Kaynak
Turkish Journal of Biochemistry
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
46
Sayı
5
Künye
Unsal, V., Kolukcu, E., Firat, F., & Gevrek, F. (2021). The protective effects of sinapic acid on acute renal ischemia/reperfusion injury. In Turkish Journal of Biochemistry (Vol. 46, Issue 5, pp. 563–571). Walter de Gruyter GmbH. https://doi.org/10.1515/tjb-2021-0115
Bağlantı
https://doi.org/10.1515/tjb-2021-0115
https://www.scopus.com/record/display.uri?eid=2-s2.0-85118942138&origin=SingleRecordEmailAlert&dgcid=raven_sc_affil_en_us_email&txGid=8023c28a454719410a7907a1ee97dbd8
https://hdl.handle.net/20.500.12514/2946
https://www.webofscience.com/wos/woscc/full-record/WOS:000712261700011?AlertId=d383397b-4355-449e-9419-70f9e0e77c15&SID=D6glE3zTofonGJ9JVtx
https://www.scopus.com/record/display.uri?eid=2-s2.0-85118942138&origin=SingleRecordEmailAlert&dgcid=raven_sc_affil_en_us_email&txGid=8023c28a454719410a7907a1ee97dbd8
https://hdl.handle.net/20.500.12514/2946
https://www.webofscience.com/wos/woscc/full-record/WOS:000712261700011?AlertId=d383397b-4355-449e-9419-70f9e0e77c15&SID=D6glE3zTofonGJ9JVtx
